Splenectomy Guide to Preventing Infection

In the following, you will learn how the spleen works, why it might be removed or not function correctly, and ways to prevent serious infections.

What is the spleen?

The spleen is an organ that removes damaged red blood cells from the bloodstream. It also protects the body against bloodstream infection by removing bacteria from the blood. If the spleen is surgically removed or does not work correctly, a minor infection can potentially develop into a life-threatening infection known as sepsis. Fortunately, treatments to prevent minor infections from becoming life-threatening can be effective when taken as soon as symptoms appear.

The spleen is located in the upper left side of the abdomen that filters bacteria from the bloodstream and is important for fighting infection.

Reasons the spleen may be removed or not function:

  • The spleen may be surgically removed for a number of reasons, including:
  • The spleen has been damaged by an injury, accident, or abdominal surgery
  • To treat an underlying medical condition such as thrombocytopenia (low platelet levels), certain leukemias or lymphomas
  • Over-activity of the spleen

In other cases, the spleen may not work properly due to an underlying condition, such as:

  • Sickle cell disease or another inherited blood disease
  • Disease or conditions in which there are abnormalities in the breakdown of red blood cells
  • Collagen vascular diseases, such as systemic lupus erythematosus (rare)
  • Absence of the spleen at birth (rare)

What is sepsis?

Sepsis is a severe and potentially life-threatening condition in which infection-causing bacteria spread throughout the bloodstream and/or tissues and impair normal body functions. In people whose spleen is removed or does not function properly, the most common cause of sepsis is infection with a bacterium called Streptococcus pneumoniae, also known as the pneumococcus.

Less commonly, sepsis develops as a result of infection with other bacteria, such as Neisseria meningitidis or Haemophilus influenzae type B (Hib). N. meningitidis and Hib were previously common causes of meningitis and other serious infections in children before vaccines to prevent these infections became available. Hib can also cause upper respiratory tract infection.

What are sepsis symptoms?

In people without a spleen or with abnormal spleen function, symptoms of sepsis may develop quickly after a minor infection, such as a respiratory tract infection. Early symptoms of a respiratory infection can include throat or chest pain, coughing, ear pain, or sinus pain and congestion, sometimes accompanied initially by low-grade fever.

In other cases, sepsis develops abruptly without any early symptoms. Symptoms can become severe quickly. People without a functional spleen should begin antibiotic treatment and seek medical care at the earliest sign or symptom of sepsis, including:

  • Fever greater than 100.4ºF or 38ºC
  • Uncontrollable chills and/or shivering
  • Headache
  • Drowsiness, confusion and/or disorientation
  • Nausea, vomiting and/or diarrhea
  • Severe abdominal pain
  • Pinpoint purplish red spots on the skin (petechiae) or larger bluish bruises
  • Low blood pressure, lightheadedness or fainting (syncope)
  • Rapid heart rate

What is the risk of sepsis?

If the spleen stops working normally or is surgically removed, the body’s immune system can usually compensate. However, there is a small but significant risk of sepsis. The risk of sepsis is highest in the following groups:

  • Children whose spleens are removed during infancy
  • People with lymphoma who are treated with splenectomy, radiation, and chemotherapy

Sepsis can also develop in otherwise healthy adults who have had their spleen removed, particularly in the first few years following splenectomy. The lifetime risk of sepsis after splenectomy is about 1 to 2 percent.

Fortunately, taking certain precautions can reduce the risk of developing sepsis.

How to prevent sepsis

All people without a functional spleen are advised to take certain precautions to help reduce the risk of developing sepsis.

Inform healthcare providers – Inform all doctors, dentists, and other members of the healthcare team that the spleen has been removed or does not function properly, especially when seeing new providers in an urgent care setting or emergency ward. Carry a patient identification card, a Medic Alert bracelet or necklace, or other medical identification indicating that the spleen has been removed or does not work properly.

Immunizations – Experts recommend that people without a functional spleen have certain vaccinations to reduce the risk of sepsis. Although these vaccines do not prevent all infections with pneumococcus, H. influenzae type B (Hib), and meningococcus, they can protect most people and reduce the severity of infection in others. When possible, vaccines should be given at least two weeks before planned surgical removal of the spleen. The vaccine should be given 14 or more days after emergency removal of the spleen (eg, due to trauma). The following recommendations are intended for people in the United States without a functional spleen; recommendations in other countries may differ:

  • Pneumococcal vaccine – Pneumococcal vaccine is recommended for all people who do not have a functional spleen. Two types of pneumococcal vaccines are available, PPSV23 and PCV13. Young children receive PCV13 as part of their routine infant immunizations. PCV13 is also recommended for adults who do not have a functional spleen. In addition, PPSV23 is recommended for adults and children ≥2 years who do not have a functional spleen. When possible, PPSV23 is given at least eight weeks after PCV13 immunization. (See “Patient education: Vaccines for infants and children age 0 to 6 years (Beyond the Basics)” and “Patient education: Adult vaccines (Beyond the Basics)“.)
  • Hib vaccine – Most adults have been exposed to Hib and are therefore immune. However, because there is a small risk that the person is not immune, experts advise people without a functional spleen to have the Hib vaccine if it was not given previously (it became available in the United States in 1988). If a person is unsure if the vaccine was given during childhood, a blood test can be done to determine if he or she is immune. (See “Patient education: Adult vaccines (Beyond the Basics)“.)
  • Meningococcal vaccine – A meningococcal conjugate vaccine (MCV4; Menactra or Menveo) and a meningococcal serogroup B vaccine (Trumenba or Bexsero) are recommended for people without a functional spleen.
  • Influenza vaccine – Influenza (the flu), a highly contagious viral infection, is a common cause of pneumonia and other bacterial infections. Therefore, a once-yearly influenza vaccination (usually given in the fall) is recommended for people without a functional spleen. (See “Patient education: Influenza symptoms and treatment (Beyond the Basics)“.)

Booster vaccines – Additional (“booster”) doses of the pneumococcal and meningococcal vaccines may be recommended to help maintain immunity. The need for a booster depends upon the individual’s situation and the type of vaccine previously given. A booster dose of the Hib vaccine is not routinely needed but is occasionally given to those who do not develop a good antibody response to the vaccine.

Preventive antibiotic therapy – Antibiotics are recommended in some people without a functional spleen to reduce the risk of developing sepsis. Two approaches are common:

  • Daily preventive antibiotic therapy
  • Antibiotic therapy for fever when needed

Daily therapy – Taking an antibiotic on a daily basis can significantly reduce the risk of infection and death, especially in children who have undergone splenectomy. Children with sickle cell anemia who have impaired spleen function may also benefit from daily antibiotic treatment. Because the risk of sepsis is low in adults, the value of daily antibiotic treatment for adults is debated.

Antibiotics for fever – People without a functional spleen are usually advised to keep a full course of antibiotics on hand, in case of illness. The antibiotic should be taken at the first sign of infection, such as fever, chills, sore throat or cough. Other signs and symptoms of infection are discussed above. After taking the first dose, the person should seek care immediately at the nearest urgent care facility to determine if further testing or treatment is needed.

Recommendations for international travel – Before traveling abroad, people without a functional spleen should consult their healthcare provider or a travel medicine center. In some cases, additional vaccinations will be recommended; one or more medications may also be prescribed to prevent or treat certain travel-related infectious diseases.

What is babesiosis?

Babesiosis is a tick-borne infection that is caused by a parasite. If infected with babesiosis, people without a functional spleen can develop a flu-like illness leading to potentially life-threatening complications. Treatment for babesiosis is available and is usually effective.

In the United States, most cases of babesiosis have occurred in southern New England (Connecticut, Massachusetts, and Rhode Island), coastal mid-Atlantic states (New Jersey, New York), and the Midwest (Michigan, Wisconsin). There have also been reports of infection in Maryland, Virginia, California, Washington State, Georgia and Indiana.

Last updated: Sep 07, 2017


Author: Mark S Pasternack, MD
Section Editor: Peter F Weller, MD, MACP
Deputy Editor: Anna R Thorner, MD

Contributor Disclosures


  1. Di Sabatino A, Carsetti R, Corazza GR. Post-splenectomy and hyposplenic states. Lancet 2011; 378:86.
  2. Davies JM, Lewis MP, Wimperis J, et al. Review of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen: prepared on behalf of the British Committee for Standards in Haematology by a working party of the Haemato-Oncology task force. Br J Haematol 2011; 155:308.
  3. American Academy of Pediatrics. Pneumococcal infections. In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed, Kimberlin DW, Brady MT, Jackson MA, Long SS (Eds), American Academy of Pediatrics, Elk Grove Village, IL 2015. p.626.

Topic 3994 Version 15.0